How is subcutaneous methotrexate different from methotrexate pills?

Methotrexate can be given many ways, depending on your condition. For conditions such as rheumatoid arthritis, psoriasis, or active polyarticular juvenile idiopathic arthritis (pJIA), patients can give themselves methotrexate orally in pills or subcutaneously by injecting methotrexate solution. When methotrexate is injected subcutaneously, it is given through a syringe or an auto-injector pen.

There are different dosages for methotrexate pills and methotrexate solution administered through syringes or auto-injector pens. If you need to take methotrexate, your doctor will decide what dosage is right for you.

When methotrexate is taken as an injection, the body absorbs it in a different way than when it is taken orally. Studies have shown that patients who take subcutaneous methotrexate may have a better response to treatment and find it easier on their stomach than methotrexate taken by mouth.