Individual people may have different sensitivities to being injected by any kind of needle or device. However, auto-injector pens were created to make it easy for people to inject themselves.
Pens that automatically inject methotrexate subcutaneously are no different; they were designed to ease the process of self-injection. Studies have shown that people using subcutaneous methotrexate auto-injector pens found them easy to use. Many patients using one type of subcutaneous methotrexate auto-injector pens have noted the injections were relatively pain-free.